Published Data Registry

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TitleAuthorsJournalPublication year
Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice(Open Access) Kaurani L, Islam MR, (...), Fischer AEMBO Journal2024
Gender-Specific Effects on the Cardiorespiratory System and Neurotoxicity of Intermittent and Permanent Low-Level Lead Exposures(Open Access) Shvachiy L, Amaro-Leal A, Machado F, Rocha I, Outeiro TF, Geraldes VBiomedicines2024
Author Correction: Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse(Open Access) Grabner CP, Futagi D, (...), DeVries SHNature Communications2024
Spatial proteomics in neurons at single-protein resolution(Open Access) Unterauer EM, Shetab Boushehri S, (...), Jungmann RCell2024
Membrane fission via transmembrane contact(Open Access) Spencer RKW, Santos-Pérez I, Rodríguez-Renovales I, Martinez Galvez JM, Shnyrova AV, Müller MNature Communications2024
Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion(Open Access) López-Murcia FJ, Lin K, (...), Taschenberger HProceedings of the National Academy of Sciences of the United States of America2024
α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway(Open Access) Oliveira da Silva MI, Santejo M, (...), Liz MACell Death & Disease2024
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid(Open Access) Aubrey LD, Ninkina N, (...), Radford SEProceedings of the National Academy of Sciences of the United States of America2024
Advancing cell biology with nanoscale fluorescence imaging: essential practical considerations(Open Access) DʼEste E, Lukinavičius G, Lincoln R, Opazo F, Fornasiero EFTrends in Cell Biology2024
H3 Acetylation-Induced Basal Progenitor Generation and Neocortex Expansion Depends on the Transcription Factor Pax6(Open Access) Sokpor G, Kerimoglu C, (...), Tuoc TBiology2024
Vesicle condensation induced by synapsin: condensate size, geometry, and vesicle shape deformations(Open Access) Alfken J, Neuhaus C, (...), Salditt TEuropean Physical Journal E2024
Dynamic gain decomposition reveals functional effects of dendrites, ion channels and input statistics in population codingZhang C, Revah O, Wolf F, Neef AJournal of Neuroscience2024
Subcellular protein turnover in human neural progenitor cells revealed by correlative electron microscopy and nanoscale secondary ion mass spectrometry imaging(Open Access) Lork AA, Rabasco S, Ernst C, du Toit A, Rizzoli SO, Phan NTNChemical Science2024
Near-optimal information relay by the neuronal population of layer 4 barrel cortex(Open Access) Revah O, Wolf F, Gutnick MJ, Neef AbioRxiv2024
Inhibition of 26S proteasome activity by α‐synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1(Open Access) Galka D, Ali TT, (...), Braus GHAging Cell2024
Synphilin-1 as a modulator of aSyn assembly(Open Access) Lázaro DF, Amen T, (...), Outeiro TFbioRxiv2024
A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise(Open Access) Methi A, Islam MR, (...), Fischer AMolecular Neurobiology2024
Comprehensive transcriptome analysis reveals altered mRNA splicing and post-transcriptional changes in the aged mouse brain(Open Access) Kumar NH, Kluever V, (...), Fornasiero EFNucleic Acids Research2024
NanoPlex: a universal strategy for fluorescence microscopy multiplexing using nanobodies with erasable signals(Open Access) Mougios N, Cotroneo ER, (...), Opazo FbioRxiv2024
Formation of memory assemblies through the DNA-sensing TLR9 pathway(Open Access) Jovasevic V, Wood EM, (...), Radulovic JNature2024
Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse(Open Access) Grabner CP, Futagi D, (...), DeVries SHNature Communications2023
Uncovering the molecular link between lead toxicity and Parkinson’s diseaseShvachiy L, Geraldes V, Outeiro TAntioxidants & Redox Signaling2023
Trafficking proteins show limited differences in mobility across different postsynaptic spines(Open Access) Mougios N, Opazo F, Rizzoli SO, Reshetniak SiScience2023
Phase Separation in Biology and Disease; Current Perspectives and Open Questions(Open Access) Boeynaems S, Chong S, (...), Kriwacki RJournal of Molecular Biology2023
Neurodegenerative disease of the brain: a survey of interdisciplinary approaches(Open Access) Davenport F, Gallacher J, (...), Zetterberg HJournal of The Royal Society Interface2023
Deep learning enables fast, gentle STED microscopy(Open Access) Ebrahimi V, Stephan T, (...), Han KYbioRxiv2023
Condensate biology of synaptic vesicle clusters(Open Access) Sansevrino R, Hoffmann C, Milovanovic DTrends in Neurosciences2023
A versatile Synaptotagmin-1 nanobody provides perturbation-free live synaptic imaging and low linkage-error in super-resolution microscopy(Open Access) Villa Real KQZ, Mougios N, (...), Opazo FbioRxiv2023
Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF(Open Access) Antoniou A, Auderset L, (...), Schneider ACell Reports2023
Alpha-synuclein oligomers activate nuclear factor of activated T-cells (NFAT) modulating apoptosis and synaptic homeostasis(Open Access) Sant'Anna R, Robbs BK, (...), Foguel DbioRxiv2023
Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts(Open Access) Castro-Hernández R, Berulava T, (...), Fischer AProceedings of the National Academy of Sciences of the United States of America2023
The multifaceted mitochondrial OXA insertase(Open Access) Homberg B, Rehling P, Cruz-Zaragoza LDTrends in Cell Biology2023
Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation(Open Access) Shvachiy L, Amaro-Leal A, Outeiro TF, Rocha I, Geraldes VCells2023
Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain(Open Access) Suk TR, Nguyen TT, (...), Rousseaux MWiScience2023
Impact of Phosphorylation on alpha-Synuclein Structural Determinants(Open Access) Dorn AE, de Bruyn E, (...), Carloni PbioRxiv2023
Reverse-time analysis uncovers universality classes in directional biological dynamics(Open Access) Lenner N, Eule S, Großhans J, Wolf FarXiv2023
Towards a Biological Definition of Parkinson’s Disease(Open Access) Höglinger GU, Adler CH, (...), Lang AEPreprints2023
Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens(Open Access) Kylies D, Zimmermann M, (...), Puelles VGNature Nanotechnology2023
Reverse-time analysis and boundary classification of directional biological dynamics with multiplicative noise(Open Access) Lenner N, Häring M, Eule S, Großhans J, Wolf FarXiv2023
Chemical Synthesis of Alpha‐Synuclein Proteins via Solid‐Phase Peptide Synthesis and Native Chemical Ligation(Open Access) Gatzemeier LM, Meyer F, Diederichsen U, Outeiro TFChemistry-A European Journal2023
A novel miR-99b-5p-Zbp1 pathway in microglia contributes to the pathogenesis of schizophrenia(Open Access) Kaurani L, Islam MR, (...), Fischer AbioRxiv2023
Deep learning enables fast, gentle STED microscopy(Open Access) Ebrahimi V, Stephan T, (...), Han KYCommunications Biology2023
Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease(Open Access) Gasparotto J, Somensi N, (...), Gelain DPJournal of Neurochemistry2023
Tunable Synaptic Working Memory with Volatile Memristive Devices(Open Access) Ricci S, Kappel D, Tetzlaff C, Ielmini D, Covi EarXiv2023
AI and protein structure and function in neurological disease: relevance to disease managementOuteiro TF, Vieira TCRGNature Reviews Neurology2023
A Versatile Synaptotagmin‐1 Nanobody Provides Perturbation‐Free Live Synaptic Imaging And Low Linkage‐Error in Super‐Resolution Microscopy(Open Access) Queiroz Zetune Villa Real K, Mougios N, (...), Opazo FSmall Methods2023
Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto‐axonal target in late‐stage Parkinson's disease(Open Access) Warth Perez Arias CC, Silbern I, (...), Lingor PJournal of Neurochemistry2023
Metabolic switch from fatty acid oxidation to glycolysis in knock-in mouse model of Barth syndrome(Open Access) Chowdhury A, Boshnakovska A, (...), Rehling PEMBO Molecular Medicine2023
Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathiesChopra A, Outeiro TFBrain2023
The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis(Open Access) Sant’Anna R, Robbs BK, (...), Foguel DMolecular Medicine2023
A viral ADP-ribosyltransferase attaches RNA chains to host proteins(Open Access) Wolfram-Schauerte M, Pozhydaieva N, (...), Höfer KNature2023
Boosting of neural circuit chaos at the onset of collective oscillations(Open Access) Palmigiano A, Engelken R, Wolf FeLife2023
Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE)Oppermann Peixoto D, Bittencourt RR, (...), Pens Gelain DJournal of Neurochemistry2023
Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression(Open Access) Kaurani L, Besse M, (...), Zilles-Wegner DTranslational Psychiatry2023
Fibroblast growth factor 9 (FGF9) mediated neurodegeneration: implications for progressive multiple sclerosis?(Open Access) Thümmler K, Wrzos C, (...), Linington CNeuropathology and Applied Neurobiology2023
Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclaseEgbert JR, Silbern I, (...), Jaffe LABiology of Reproduction2023
Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm(Open Access) Grahn E, Kaufmann SV, (...), Kaupp UNature Communications2023
Synapsin condensation controls synaptic vesicle sequestering and dynamics(Open Access) Hoffmann C, Rentsch J, (...), Milovanovic DNature Communications2023
PrP meets alpha‐synuclein: Molecular mechanisms and implications for disease(Open Access) Vieira TCRG, Barros CA, Domingues R, Outeiro TFJournal of Neurochemistry2023
High-resolution analysis of bound Ca<sup>2+</sup>in neurons and synapses(Open Access) Bonnin EA, Golmohammadi A, Rehm R, Tetzlaff C, Rizzoli SOLife Science Alliance2023
Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices(Open Access) Jentoft IM, Bäuerlein FJ, (...), Schuh MCell2023
ATG9 resides on a unique population of small vesicles in presynaptic nerve terminalsBinotti B, Ninov M, (...), Jahn RAutophagy2023
FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon response(Open Access) Saxena K, Roverato ND, (...), Aichem ALife Science Alliance2023
Prediction mismatch responses arise as corrections of a predictive spiking code(Open Access) van Driel K, Rudelt L, Priesemann V, Mikulasch FAbioRxiv2023
Excess Phosphoserine-129 α-Synuclein Induces Synaptic Vesicle Trafficking and Declustering Defects at a Vertebrate Synapse(Open Access) Wallace JN, Crockford ZC, (...), Morgan JRMol Biol Cell2023
Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus(Open Access) Hintze A, Lange F, (...), Wichmann CiScience2023
Lipid vesicle pools studied by passive X-ray microrheology(Open Access) Czajka T, Neuhaus C, (...), Salditt TThe European Physical Journal E2023
Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory SynapsesAltas B, Tuffy LP, (...), Poulopoulos ABiological Psychiatry2023
B36.00008: Membrane fusion as a pathway to fission(Open Access) Spencer RK, Müller MAPS March Meeting 20242023
Age-dependent structural reorganization of utricular ribbon synapses(Open Access) Michanski S, Henneck T, (...), Wichmann CFrontiers in Cell and Developmental Biology2023
Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins(Open Access) Peifer M, Schmidt A, (...), Wolf FMolecular Biology of the Cell2023
Boosting of neural circuit chaos at the onset of collective oscillations(Open Access) Palmigiano A, Engelken R, Wolf FeLife2023
The long-loop recycling (LLR) of synaptic components as a question of economics(Open Access) Georgiev SV, Rizzoli SOMolecular and Cellular Neuroscience2023
SparseProp: Efficient Event-Based Simulation and Training of Sparse Recurrent Spiking Neural Networks(Open Access) Engelken RarXiv2023
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease(Open Access) Hatton C, Ghanem SS, (...), Erskine DBrain2022
Signals from the interface: protein nanoclusters stabilize biomolecular condensates(Open Access) Hoffmann C, Rankovic B, Milovanovic DSignal Transduct Target Ther2022
Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation(Open Access) Torres-Garcia L, P. Domingues JM, (...), Li JScientific Reports2022
Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes(Open Access) Chang HF, Schirra C, (...), Rettig JNature Communications2022
Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3Upmanyu N, Jin J, (...), Sambandan SNeuron2022
Methods for multiscale structural and functional analysis of the mammalian cochleaVogl C, Neef J, Wichmann CMolecular and Cellular Neuroscience2022
DiSCERN - Deep Single Cell Expression ReconstructioN for improved cell clustering and cell subtype and state detection(Open Access) Hausmann F, Ergen-Behr C, (...), Bonn SbioRxiv2022
Extracellular alpha-synuclein: Sensors, receptors, and responses(Open Access) Domingues R, Sant’Anna R, da Fonseca ACC, Robbs BK, Foguel D, Outeiro TFNeurobiology of Disease2022
The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains(Open Access) Peña-Díaz S, Pujols J, (...), Ventura SJournal of Biological Chemistry2022
Extracellular Matrix Recycling as a Novel Plasticity Mechanism With a Potential Role in Disease(Open Access) Dankovich TM, Rizzoli SOFrontiers in Cellular Neuroscience2022
The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible(Open Access) Cassotta MALTEX-Alternatives to Animal Experimentation2022
Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses(Open Access) Chakrabarti R, Jaime Tobón LM, (...), Wichmann CbioRxiv2022
Optimal precision and accuracy in 4Pi-STORM using dynamic spline PSF models(Open Access) Bates M, Keller-Findeisen J, (...), Hell SWNature Methods2022
An iodine-containing probe as a tool for molecular detection in secondary ion mass spectrometry(Open Access) Kabatas Glowacki S, Agüi-Gonzalez P, (...), Rizzoli SOChemical Communications2022
Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations(Open Access) Buratti FA, Boeffinger N, (...), Fernández COProtein Science2022
Resolving the molecular architecture of the photoreceptor active zone with 3D-MINFLUX(Open Access) Grabner CP, Jansen I, (...), Moser TScience Advances2022
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species(Open Access) Santos CC, Cardim-Pires TR, (...), Silva VDANeurotoxicity Research2022
Ectosomes and exosomes modulate neuronal spontaneous activityBrás IC, Khani MH, (...), Outeiro TFJournal of Proteomics2022
Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes(Open Access) Chegão A, Guarda M, (...), Vicente Miranda Hnpj Parkinson's Disease2022
Extracellular vesicles derived from the choroid plexus trigger the differentiation of neural stem cells(Open Access) Ditte Z, Silbern I, Ditte P, Urlaub H, Eichele GJournal of Extracellular Vesicles2022
Focused ion beam‐scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag(Open Access) Steyer AM, Buscham TJ, (...), Werner HBGlia2022
Where is the error? Hierarchical predictive coding through dendritic error computation(Open Access) Mikulasch FA, Rudelt L, Wibral M, Priesemann VTrends in Neurosciences2022
ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control(Open Access) Khan MN, Cherukuri P, (...), Marquardt TPLOS Biology2022
Abstract: A10.00009 : The role of protein constriction in the fission of membrane tubes(Open Access) Spencer RK, Müller MAPS March Meeting 20232022
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies(Open Access) Koss DJ, Erskine D, (...), Outeiro TFActa Neuropathologica Communications2022
Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses(Open Access) Chakrabarti R, Jaime Tobón LM, (...), Wichmann CeLife2022
Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells(Open Access) Vasili E, Dominguez-Meijide A, (...), Outeiro TFMolecular Neurobiology2022
Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways(Open Access) Schaffner SL, Wassouf Z, (...), Kobor MSHuman Molecular Genetics2022
Age-dependent structural reorganization of utricular ribbon synapses(Open Access) Michanski S, Henneck T, (...), Wichmann CbioRxiv2022
Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal ActivityBrás IC, Khani MH, (...), Outeiro TFJournal of Parkinsons Disease2022
Conserved reduction of m<sup>6</sup>A marks during aging and neurodegeneration is linked to altered translation of synaptic transcripts(Open Access) Castro-Hernández R, Berulava T, (...), Fischer AbioRxiv2022
Boosting of neural circuit chaos at the onset of collective oscillations(Open Access) Palmigiano A, Engelken R, Wolf FbioRxiv2022
From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms(Open Access) Shvachiy L, Amaro-Leal A, Outeiro TF, Rocha I, Geraldes VBiology (Basel)2022
The Synaptic Extracellular Matrix: Long-Lived, Stable, and Still Remarkably Dynamic(Open Access) Dankovich TM, Rizzoli SOFrontiers in Synaptic Neuroscience2022
Alpha-Synuclein Antibody Characterization: Why Semantics Matters(Open Access) Outeiro TFMolecular Neurobiology2021
Non-negative Matrix Factorization as a Tool to Distinguish Between Synaptic Vesicles in Different Functional StatesNeher E, Taschenberger HNeuroscience2021
Exploring early time points of vimentin assembly in flow by fluorescence fluctuation spectroscopyPerego E, Köster SLab on a Chip2021
NanoSIMS observations of mouse retinal cells reveal strict metabolic controls on nitrogen turnover(Open Access) Bonnin EA, Fornasiero EF, Lange F, Turck CW, Rizzoli SOBMC Molecular and Cell Biology2021
Challenges facing quantitative large-scale optical super-resolution, and some simple solutions(Open Access) Dankovich TM, Rizzoli SOiScience2021
Intranuclear immunostaining-based FACS protocol from embryonic cortical tissue(Open Access) Sakib MS, Sokpor G, Nguyen HP, Fischer A, Tuoc TSTAR Protocols2021
Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders(Open Access) Erskine D, Koss D, Korolchuk VI, Outeiro TF, Attems J, McKeith IActa Neuropathologica2021
Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy(Open Access) Reinert M, Pacheu-Grau D, (...), Brockmann KOrphanet Journal of Rare Diseases2021
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation(Open Access) Jafari M, Schumacher A, (...), Kerschensteiner MNature Neuroscience2021
Hippocampal neurons respond to brain activity with functional hypoxia(Open Access) Butt UJ, Steixner-Kumar AA, (...), Ehrenreich HMolecular Psychiatry2021
Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo(Open Access) Dominguez-Meijide A, Parrales V, (...), Outeiro TFNeurobiology of Disease2021
Protein phosphorylation in depolarized synaptosomes: Dissecting primary effects of calcium from synaptic vesicle cycling(Open Access) Silbern I, Pan K, (...), Jahn RMolecular & Cellular Proteomics2021
Monitoring mitochondrial translation in living cells(Open Access) Yousefi R, Fornasiero EF, (...), Pacheu‐Grau DEMBO Reports2021
Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality(Open Access) Bonilla-Quintana M, Wörgötter F, D’Este E, Tetzlaff C, Fauth MScientific Reports2021
Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients(Open Access) Zhao Y, Kilian C, (...), Krebs CFScience Immunology2021
The Coding and Small Non-coding Hippocampal Synaptic RNAome(Open Access) Epple R, Krüger D, (...), Fischer AMolecular Neurobiology2021
Cofilin pathology is a new player on α-synuclein-induced spine impairment in models of hippocampal synucleinopathy(Open Access) Oliveira da Silva MI, Santejo M, (...), Liz MbioRxiv2021
Ultrastructural maturation of endbulb of Held active zones comparing wild-type and otoferlin-deficient mice(Open Access) Hintze A, Gültas M, Semmelhack EA, Wichmann CiScience2021
The vesicle cluster as a major organizer of synaptic composition in the short-term and long-term(Open Access) Reshetniak S, Rizzoli SOCurrent Opinion in Cell Biology2021
RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses(Open Access) Krinner S, Predoehl F, Burfeind D, Vogl C, Moser TFrontiers in Molecular Neuroscience2021
The effect of polydispersity, shape fluctuations and curvature on small unilamellar vesicle small-angle X-ray scattering curves(Open Access) Chappa V, Smirnova Y, Komorowski K, Müller M, Salditt TJournal of Applied Crystallography2021
Synapsin Condensates Recruit alpha-Synuclein(Open Access) Hoffmann C, Sansevrino R, (...), Milovanovic DJournal of Molecular Biology2021
Presynaptic activity and protein turnover are correlated at the single-synapse level(Open Access) Jähne S, Mikulasch F, (...), Priesemann VCell Reports2021
Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex(Open Access) Ulmke PA, Sakib MS, (...), Tuoc TStem Cell Reports2021
Secondary Ion Mass Spectrometry Imaging Reveals Changes in the Lipid Structure of the Plasma Membranes of Hippocampal Neurons following Drugs Affecting Neuronal Activity(Open Access) Agüi-Gonzalez P, Guobin B, Gomes de Castro MA, Rizzoli SO, Phan NTNACS Chemical Neuroscience2021
Gold-conjugated Nanobodies for Targeted Imaging using High-resolution Secondary Ion Mass Spectrometry(Open Access) Agüi-Gonzalez P, Dankovich TM, Opazo F, Rizzoli SO, Phan NTPreprints2021
Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways(Open Access) Schaffner SL, Wassouf Z, (...), Kobor MSbioRxiv2021
Super-resolution microscopy informs on the molecular architecture of alpha-synuclein inclusions in model systems and in the human brain(Open Access) Weish P, Lazaro DF, (...), Outeiro TFbioRxiv2021
RIM-Binding Protein 2 organizes Ca2+ channel topography and regulates release probability and vesicle replenishment at a fast central synapse(Open Access) Butola T, Alvanos T, (...), Moser TbioRxiv2021
Dysfunction of RAB39B‐Mediated Vesicular Trafficking in Lewy Body Diseases(Open Access) Koss DJ, Campesan S, Giorgini F, Outeiro TFMovement Disorders2021
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines(Open Access) Helm MS, Dankovich TM, (...), Rizzoli SONature Neuroscience2021
Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein(Open Access) Martinez Hernandez A, Silbern I, (...), Eichele GFrontiers in Neuroscience2021
Allosteric transcription stimulation by RNA polymerase II super elongation complexChen Y, Vos SM, Dienemann C, Ninov M, Urlaub H, Cramer PMolecular Cell2021
Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells(Open Access) Brás IC, Khani MH, (...), Outeiro TFbioRxiv2021
Surface tension and viscosity of protein condensates quantified by micropipette aspiration(Open Access) Wang H, Kelley FM, Milovanovic D, Schuster BS, Shi ZBiophysical Reports2021
Cellular Prion Protein Mediates α‐Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo(Open Access) Thom T, Schmitz M, (...), Zerr IMovement Disorders2021
Differences in synaptic vesicle pool behavior between male and female hippocampal cultured neurons(Open Access) Sertel SM, Blumenstein W, Mandad S, Shomroni O, Salinas G, Rizzoli SOScientific Reports2021
Tubular microdomains of Rab7-endosomes retrieve TrkA, a mechanism disrupted in Charcot-Marie-Tooth 2BMarkworth R, Dambeck V, (...), Burk KJournal of Cell Science2021
Management of Metadata Types in Basic Cardiological Research(Open Access) Kusch H, Kossen R, (...), Nussbeck SYStudies in Health Technology and Informatics2021
Bias-invariant RNA-sequencing metadata annotation(Open Access) Wartmann H, Heins S, Kloiber K, Bonn SGigascience2021
Principles of brain aging: Status and challenges of modeling human molecular changes in miceKluever V, Fornasiero EFAgeing Research Reviews2021
GMDS2021 ePoster and video teaser for DOI 10.3205/21gmds072(Open Access) Kusch H, Bauer CR, (...), Sax UGöttingen Research Online / Data2021
Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501(Open Access) Goldberg M, Islam MR, (...), Fischer ATranslational Psychiatry2021
The mammalian rod synaptic ribbon is essential for Cav channel facilitation and ultrafast synaptic vesicle fusion(Open Access) Grabner CP, Moser TeLife2021
Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission(Open Access) Lipstein N, Chang S, (...), Brose NNeuron2021
Heterogeneity of glutamatergic synapses: cellular mechanisms and network consequences(Open Access) Wichmann C, Kuner TPhysiological Reviews2021
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy(Open Access) Kettwig M, Ternka K, (...), Gärtner JNature Communications2021
Three-dimensional virtual histology of the cerebral cortex based on phase-contrast X-ray tomography(Open Access) Eckermann M, van der Meer F, (...), Salditt TBiomedical Optics Express2021
Punctuated evolution of visual cortical circuits? Evidence from the large rodent Dasyprocta leporina, and the tiny primate Microcebus murinus(Open Access) Schmidt KE, Wolf FCurrent Opinion in Neurobiology2021
Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and the regulation of neuron‐enriched genes(Open Access) Michurina A, Sakib MS, (...), Fischer AEMBO Journal2021
Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R(Open Access) Dankovich TM, Kaushik R, (...), Rizzoli SONature Communications2021
Endogenous Levels of Alpha-synuclein Modulate Seeding and Aggregation in Cultured Cells(Open Access) Vasili E, Dominguez-Meijide A, (...), Outeiro TResearchsquare2021
RIM-Binding Protein 2 Organizes Ca2+ Channel Topography and Regulates Release Probability and Vesicle Replenishment at a Fast Central Synapse(Open Access) Butola T, Alvanos T, (...), Moser TThe Journal of Neuroscience2021
A microRNA signature that correlates with cognition and is a target against cognitive decline(Open Access) Islam MR, Kaurani L, (...), Fischer AEMBO Molecular Medicine2021
Conditional Loss of BAF (mSWI/SNF) Scaffolding Subunits Affects Specification and Proliferation of Oligodendrocyte Precursors in Developing Mouse Forebrain(Open Access) Abbas E, Hassan MA, (...), Tuoc TFrontiers in Cell and Developmental Biology2021
Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease(Open Access) Oliveira LMA, Gasser T, (...), Outeiro TFnpj Parkinson's Disease2021
Co-localization of different neurotransmitter transporters on synaptic vesicles is sparse except of VGLUT1 and ZnT3(Open Access) Upmanyu N, Jin J, (...), Sambandan SbioRxiv2021
Monitoring Alpha-Synuclein – Tau Interactions In Vitro and In Vivo Using Bimolecular Fluorescence Complementation(Open Access) Torres-Garcia L, Domingues JM, (...), Li JResearchsquare2021
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies(Open Access) Koss DJ, Erskine D, (...), Outeiro TFbioRxiv2021
Resolving the molecular architecture of the photoreceptor active zone by MINFLUX nanoscopy(Open Access) Grabner CP, Jansen I, (...), Moser TbioRxiv2021
Gold-Conjugated Nanobodies for Targeted Imaging Using High-Resolution Secondary Ion Mass Spectrometry(Open Access) Agüi-Gonzalez P, Dankovich TM, Rizzoli SO, Phan NTNNanomaterials2021
Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranesToth A, Meyrat A, (...), Ott MProceedings of the National Academy of Sciences of the United States of America2020
MINFLUX nanoscopy delivers 3D multicolor nanometer resolution in cellsGwosch KC, Pape JK, (...), Hell SWNature Methods2020
Leaflet-dependent distribution of PtdIns[4,5]P2 in supported model membranesSchäfer J, Nehls J, Schön M, Mey IP, Steinem CLangmuir2020
Synucleinopathies: Where we are and where we need to go(Open Access) Brás IC, Dominguez‐Meijide A, (...), Outeiro TFJournal of Neurochemistry2020
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing FactorsLuo L, Ambrozkiewicz MC, (...), Craig AMNeuron2020
Light Microscopy of Mitochondria at the NanoscaleJakobs S, Stephan T, Ilgen P, Brüser CAnnual Review of Biophysics2020
Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses(Open Access) Maus L, Lee C, (...), Cooper BHCell Reports2020
Protein trapping leads to altered synaptic proteostasis in synucleinopathies(Open Access) Santos PI, Outeiro TFThe FEBS Journal2020
X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(i)/copper(ii)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathyCukierman DS, Lázaro DF, (...), Rey NADalton Transactions2020
Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer’s DiseaseHarris SS, Wolf F, De Strooper B, Busche MANeuron2020
A comparative analysis of the mobility of 45 proteins in the synaptic bouton(Open Access) Reshetniak S, Ußling J, (...), Rizzoli SOEMBO Journal2020
The Role of Alpha-Synuclein And Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders(Open Access) Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF, Schüle BPreprints2020
Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids(Open Access) Zafeiriou M, Bao G, (...), Zimmermann WNature Communications2020
Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices(Open Access) Imig C, López-Murcia FJ, (...), Cooper BHNeuron2020
A streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics(Open Access) Fang P, Ji Y, (...), Urlaub HNature Communications2020
Increased expression of myelin-associated genes in frontal cortex of <i>SNCA</i> overexpressing rats and Parkinson's disease patients.(Open Access) Hentrich T, Wassouf Z, (...), Schulze-Hentrich JMAging-US2020
Neuropathology of patients with COVID-19 in Germany: a post-mortem case series(Open Access) Matschke J, Lütgehetmann M, (...), Glatzel MLancet Neurology2020
Neuroligin-2 dependent conformational activation of Collybistin reconstituted in supported hybrid membranesSchäfer J, Förster L, Mey I, Papadopoulos T, Brose N, Steinem CJournal of Biological Chemistry2020
From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's DiseaseOuteiro TF, Heutink P, Bezard E, Cenci AMMovement Disorders2020
Synaptic activity and strength are reflected by changes in the post-synaptic secretory pathway(Open Access) Gürth C, Dankovich TM, Rizzoli SO, D’Este EScientific Reports2020
A minimalist model to measure interactions between proteins and synaptic vesicles(Open Access) Perego E, Reshetniak S, (...), Köster SScientific Reports2020
The mRNA-binding protein RBM3 regulates activity patterns and local synaptic translation in cultured hippocampal neurons(Open Access) Sertel SM, von Elling-Tammen MS, Rizzoli SOThe Journal of Neuroscience2020
Rho‐Kinase Inhibition by Fasudil Modulates Presynaptic Vesicle Dynamics(Open Access) Saal KA, Warth Pérez Arias C, (...), Lingor PJournal of Neurochemistry2020
Deep learning–based cell composition analysis from tissue expression profiles(Open Access) Menden K, Marouf M, (...), Bonn SScience Advances2020
Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus(Open Access) Sato M, Mizuta K, (...), Hayashi YCell Reports2020
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol(Open Access) Gerdes C, Waal N, (...), Opazo FNature Communications2020
Vesicle adhesion in the electrostatic strong-coupling regime studied by time-resolved small-angle X-ray scattering(Open Access) Komorowski K, Schaeper J, (...), Salditt TSoft Matter2020
SUMOylation controls the neurodevelopmental function of the transcription factor Zbtb20(Open Access) Ripamonti S, Shomroni O, (...), Tirard MJournal of Neurochemistry2020
An experimentally generated peptide database increases the sensitivity of XL-MS with complex samplesParfentev I, Schilbach S, Cramer P, Urlaub HJournal of Proteomics2020
Modeling the Shape of Synaptic Spines by Their Actin Dynamics(Open Access) Bonilla-Quintana M, Wörgötter F, Tetzlaff C, Fauth MFrontiers in Synaptic Neuroscience2020
The self-organized learning of noisy environmental stimuli requires distinct phases of plasticity(Open Access) Krüppel S, Tetzlaff CNetwork Neuroscience2020
Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases(Open Access) Lázaro DF, Bellucci A, Brundin P, Outeiro TFFrontiers in Molecular Neuroscience2020
Realistic in silico generation and augmentation of single-cell RNA-seq data using generative adversarial networks(Open Access) Marouf M, Machart P, (...), Bonn SNature Communications2020
Post-translational modifications soften vimentin intermediate filaments(Open Access) Kraxner J, Lorenz C, (...), Köster SNanoscale2020
The Coding And Small-Non-Coding Hippocampal Synaptic RNAome(Open Access) Epple R, Krüger D, (...), Fischer AbioRxiv2020
Local translation in synaptic mitochondria influences synaptic transmission(Open Access) Yousefi R, Fornasiero EF, (...), Pacheu-Grau DbioRxiv2020
RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies(Open Access) Koss DJ, Bondarevaite O, (...), Outeiro TFBrain Pathology2020
The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders(Open Access) Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF, Schüle BInternational Journal of Molecular Sciences2020
Quantitative Synaptic Biology: A Perspective on Techniques, Numbers and Expectations(Open Access) Reshetniak S, Fernández-Busnadiego R, Müller M, Rizzoli SO, Tetzlaff CInternational Journal of Molecular Sciences2020
Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo(Open Access) Dominguez-Meijide A, Parrales V, (...), Outeiro TFbioRxiv2020
Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R(Open Access) Dankovich TM, Kaushik R, (...), Rizzoli SObioRxiv2020
Are genetic and idiopathic forms of Parkinson’s disease the same disease?(Open Access) Correia Guedes L, Mestre T, Outeiro TF, Ferreira JJJournal of Neurochemistry2019
A practical guide to optimization in X10 expansion microscopyTruckenbrodt S, Sommer C, Rizzoli SO, Danzl JGNature Protocols2019
Principles underlying the input-dependent formation and organization of memories(Open Access) Herpich J, Tetzlaff CNetwork Neuroscience2019
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies(Open Access) Szegő ÉM, Dominguez-Meijide A, (...), Outeiro TFCell Reports2019
Interrogating Synaptic Architecture: Approaches for Labeling Organelles and Cytoskeleton Components(Open Access) Reshetniak S, Rizzoli SOFrontiers in Synaptic Neuroscience2019
Deep-learning-based cell composition analysis from tissue expression profilesMenden K, Marouf M, Dalmia A, Heutink P, Bonn SbioRxiv2019
Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity(Open Access) Carija A, Pinheiro F, (...), Ventura SRedox Biology2019
A Theoretical Framework to Derive Simple, Firing-Rate-Dependent Mathematical Models of Synaptic Plasticity(Open Access) Lappalainen J, Herpich J, Tetzlaff CFrontiers in Computational Neuroscience2019
In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategiesMarvian AT, Koss DJ, Aliakbari F, Morshedi D, Outeiro TFJournal of Neurochemistry2019
Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O2 Consumption and ROS Release(Open Access) Can K, Menzfeld C, (...), Müller MFrontiers in Physiology2019
Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of ParkinsonismGong J, Szego ÉM, (...), Schneider AThe Journal of Neuroscience2019
SIMS imaging in neurobiology and cell biology(Open Access) Agüi-Gonzalez P, Jähne S, Phan NTNJournal of Analytical Atomic Spectrometry2019
The Contribution of Iron to Protein Aggregation Disorders in the Central Nervous System(Open Access) Joppe K, Roser A, Maass F, Lingor PFrontiers in Neuroscience2019
Correlating Synaptic Ultrastructure and Function at the Nanoscale(Open Access) Maus L, Altas B, Rhee J, Brose N, Imig C, Cooper BHbioRxiv2019
Correlative STED super-resolution light and electron microscopy on resin sectionsWurm CA, Schwarz H, Jans DC, Riedel D, Humbel BM, Jakobs SJournal of Physics D-Applied Physics2019
Deep Learning and Random Forest-Based Augmentation of sRNA Expression ProfilesFiosina J, Fiosins M, Bonn SLecture Notes in Computer Science2019
LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?(Open Access) Outeiro TF, Harvey K, Dominguez-Meijide A, Gerhardt EBiochemical Society Transactions2019
Epigenetics of the Synapse in Neurodegeneration(Open Access) Xylaki M, Atzler B, Outeiro TFCurrent Neurology and Neuroscience Reports2019
Investigating targets for neuropharmacological intervention by molecular dynamics simulations(Open Access) Rossetti G, Kless A, Lai L, Outeiro TF, Carloni PBiochemical Society Transactions2019
Live-cell STED nanoscopy of mitochondrial cristae(Open Access) Stephan T, Roesch A, Riedel D, Jakobs SScientific Reports2019
Fluorinated nanobodies for targeted molecular imaging of biological samples using nanoscale secondary ion mass spectrometry(Open Access) Kabatas S, Agüi-Gonzalez P, (...), Phan NTNJournal of Analytical Atomic Spectrometry2019
A 2A R‐induced transcriptional deregulation in astrocytes: An in vitro studyPaiva I, Carvalho K, (...), Blum DGlia2019
Live-cell STED microscopy of mitochondrial cristae(Open Access) Stephan T, Roesch A, Riedel D, Jakobs SbioRxiv2019
Synuclein Meeting 2019: where we are and where we need to goOuteiro TF, Mestre TAJournal of Neurochemistry2019
Tagger—A Swiss army knife for multiomics to dissect cell type–specific mechanisms of gene expression in mice(Open Access) Kaczmarczyk L, Bansal V, (...), Jackson WSPLOS Biology2019
Nanomachinery Organizing Release at Neuronal and Ribbon Synapses(Open Access) Chakrabarti R, Wichmann CInternational Journal of Molecular Sciences2019
The self-organized learning of noisy environmental stimuli requires distinct phases of plasticity(Open Access) Krüppel S, Tetzlaff CbioRxiv2019
The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43(Open Access) Keihani S, Kluever V, (...), Fornasiero EFScience Advances2019
Explainable Deep Learning for Augmentation of Small RNA Expression Profiles(Open Access) Fiosina J, Fiosins M, Bonn SJournal of Computational Biology2019
Explainable Deep Learning for Augmentation of sRNA Expression Profiles(Open Access) Fiosina J, Fiosins M, Bonn SarXiv2019
Mechanisms of alpha-synuclein toxicity: An update and outlookBrás IC, Xylaki M, Outeiro TFProgress in Brain Research2019
A mass spectrometry workflow for measuring protein turnover rates in vivo(Open Access) Alevra M, Mandad S, Ischebeck T, Urlaub H, Rizzoli SO, Fornasiero EFNature Protocols2019
A combined miRNA–piRNA signature to detect Alzheimer’s disease(Open Access) Jain G, Stuendl A, (...), Fischer ATranslational Psychiatry2019
Seeding variability of different alpha synuclein strains in synucleinopathiesCandelise N, Schmitz M, (...), Zerr IAnnals of Neurology2019
Boron‐Containing Probes for Non‐optical High‐Resolution Imaging of Biological Samples(Open Access) Kabatas S, Agüi‐Gonzalez P, (...), Phan NTNAngewandte Chemie-International Edition2019
Combined Use of Unnatural Amino Acids Enables Dual-Color Super-Resolution Imaging of Proteins via Click ChemistrySaal K, Richter F, Rehling P, Rizzoli SOACS Nano2018
Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons(Open Access) Maidorn M, Olichon A, Rizzoli SO, Opazo FmAbs2018
The role of LRRK2 in cell signalling(Open Access) Harvey K, Outeiro TFBiochemical Society Transactions2018
Kollaboratives Forschungszentrum (Sonderforschungsbereich, SFB) 1286 „Quantitative Synaptologie“(Open Access) Schubert K, Rizzoli SONeuroforum2018
Circulating miRNAs as Diagnostic Biomarkers for Parkinson’s Disease(Open Access) Roser AE, Caldi Gomes L, Schünemann J, Maass F, Lingor PFrontiers in Neuroscience2018
Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi functionPaiva I, Jain G, (...), Outeiro TFNeurobiology of Disease2018
Membrane binding, internalization, and sorting of alpha-synuclein in the cell(Open Access) Masaracchia C, Hnida M, (...), Outeiro TFActa Neuropathologica Communications2018
Robust nanoscopy of a synaptic protein in living mice by organic-fluorophore labeling(Open Access) Masch J, Steffens H, (...), Hell SWProceedings of the National Academy of Sciences of the United States of America2018
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission(Open Access) Truckenbrodt S, Viplav A, (...), Rizzoli SOThe EMBO Journal2018
X10 expansion microscopy enables 25‐nm resolution on conventional microscopes(Open Access) Truckenbrodt S, Maidorn M, Crzan D, Wildhagen H, Kabatas S, Rizzoli SOEMBO reports2018
Sensing α-Synuclein From the Outside via the Prion Protein: Implications for NeurodegenerationBrás IC, Lopes LV, Outeiro TFMovement Disorders2018
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions(Open Access) Fornasiero EF, Mandad S, (...), Rizzoli SONature Communications2018
Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein(Open Access) Pinho R, PaivaI , (...), Outeiro TFHuman Molecular Genetics2018
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons(Open Access) Pujols J, Peña-Díaz S, (...), Ventura SProceedings of the National Academy of Sciences of the United States of America2018
SUMO1-conjugation is altered during normal aging but not by increased amyloid burden(Open Access) Stankova T, Piepkorn L, Bayer TA, Jahn O, Tirard MAging Cell2018
WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton(Open Access) Mentel M, Ionescu AE, (...), Szedlacsek SEScientific Reports2018
RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones(Open Access) Krinner S, Butola T, Jung S, Wichmann C, Moser TFrontiers in Cellular Neuroscience2017
Piccolo Promotes Vesicle Replenishment at a Fast Central Auditory Synapse(Open Access) Butola T, Wichmann C, Moser TFrontiers in Synaptic Neuroscience2017