Technical Support: sfb1286-support@gwdg.de
Department of Medical Informatics
University Medical Center Göttingen
PID | umg-sfb1286-antibody-primary-6 |
EPIC PID | https://hdl.handle.net/11022/umg-sfb1286-antibody-primary-6 |
Research group | RG Rizzoli |
Quality (mean) | no score (0.00) |
Sharing level | Public |
Antigen symbol | SNAP25 |
Antibody Registry ID(s) | AB_887790 |
Name | SNAP 25 |
Alternative name | synaptosome-associated protein 25 |
Lab ID | |
Tag / Fluorophore | |
Raised in | rabbit |
Reacts with | human, rat, mouse, hamster, chicken, goldfish |
Clone | |
Isotype | |
Clonality | polyclonal |
Demasking | unknown |
Antigen | Synthetic peptide corresponding to AA 192 to 206 from human SNAP25 |
Crafted By | company |
Company / Manufacturer | Synaptic Systems |
Catalog no. | 111 002 |
Lot no. | |
Description | WB: 1 : 10000 (AP staining) IP: yes ICC: 1 : 500 IHC: 1 : 200 IHC-P/FFPE: 1 : 500 ELISA: yes (see remarks) |
Localization | SNAP 25 (synaptosome-associated protein of 25 kDa) is a highly conserved protein anchored to thecytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP 25 is thetarget of Botulinum neurotoxin A and E which cleave off 9 and 26 amino acids, respectively, from theC-terminus. SNAP 25 is part of the exocytotic fusion complex (v-SNARE) of neurons where it assembles withsyntaxin 1 and synaptobrevin. It is abundantly localized on the neuronal plasmalemma and onrecycling vesicles including synaptic vesicles. It is also expressed in neuroendocrine cells. There aretwo splice-variants, SNAP 25A and 25B. |
Storage instruction | |
Receipt date | 2019-01-01 00:00:00 |
Preparation date | 2019-03-04 00:00:00 |
Created by | Min, Ad |
Last modified | Min, Ad |
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Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
EMBO J 2018 : 10.15252/embj.201798044